This integration began to dissolve with the advent of the Renaissance, which slowly distanced human creative energies away from the integrated organic and hierarchical structure and focused instead on emerging humanism. As humanism developed, it became increasingly domineering until it became estranged from God altogether.
Ironically enough, the disassociation of man from God was also humanism’s death knell. The breach between the Divine and human in consciousness marked the end of our collective understanding of what human "really" means, to say nothing of our collective understanding of what the world or the cosmos means.
The end of the human as a purely materialistic concept — with the supposed rights and duties ascribed to the concept— is already on the horizon in the forms of totalitarian statism and technology.
As noted, this alienation from God is fundamentally a matter of consciousness — the disunity is a perceived one rather than a “real” one. Whether he likes it or not, man is still very much associated with God, and this reality stands even when man chooses to deny the existence of God outright.
Yet man has some leverage in this via his agency and his consciousness. His rejection of God and Creation does not and cannot obliterate the reality of God and Creation; however, it can destroy God and Creation as realities within his consciousness.
Man’s turning away from God has created a state of disunified unity. The Divine and human remain fundamentally united by default, but man’s vociferous rejection of this unity in consciousness fissures and limits the operations between the Divine and the human.
God yearns to reassociate with man via consciousness, and he is waiting for man to reassociate with Him via consciousness, but He cannot impose this reassociation upon man’s consciousness. He can only meet man halfway; the other half depends entirely on man.
A return to the Medieval worldview and organic wholeness offers a potential path to reunifying with God via consciousness, but this is entirely contingent on the belief that human consciousness has not changed in any underlying or meaningful way since the Middle Ages — that alienated modern man is the same as unified Medieval man and that only way modern man can get back to God is by becoming Medieval man once again.
The answer to whether this kind of reunification/ressassociation is possible, let alone desirable, rests in the following overarching question — Why did God create man?
Expanded further, Why did God create Creation?